Endocrine Abstracts

Celastrol, a triterpene compound derived from the thunder god vine (Tripterygium wilfordii), has shown promising efficacy in preclinical models for the management of metabolic disorders such as obesity and diabetes. The compound exhibits anti-inflammatory properties and has been shown to enhance insulin sensitivity and modulate lipid metabolism. The observed weight loss effects are thought to be primarily mediated by its ability to augment leptin sensitivity. Despite extensive...

Allan-Herndon-Dudley syndrome (AHDS) is a genetic disorder characterized by intellectual disability and movement disorders. AHDS patients have mutations in the monocarboxylate transporter 8 (MCT8) that impedes thyroid hormone (TH) transport to the brain during crucial phases of brain development. In mice, the resulting structural and functional pathologies of human AHDS patients can be mimicked by knocking out murine MCT8 and the Solute Carrier Organic Anion Transporter Family...